Журнал «Почки» Том 13, №1, 2024
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Сучасна парадигма в діагностиці кістозних хвороб нирок
Авторы: Красюк І.В. (1), Денова Л.Д. (1, 2), Карпенко О.В. (1)
(1) - Національний медичний університет імені О.О. Богомольця, м. Київ, Україна
(2) - Національний університет охорони здоров’я України імені П.Л. Шупика, м. Київ, Україна
Рубрики: Нефрология
Разделы: Справочник специалиста
Версия для печати
Кістозні хвороби нирок є досить поширеною патологією, яка негативно впливає на перебіг основного захворювання, що вражає нирки, або навіть може бути первинною патологією нирок. Мета цього огляду — проаналізувати останні дані літератури щодо етіології, патогенезу, діагностики кістозних хвороб нирок. У цій статті висвітлені деякі моменти патогенезу, діагностики й лікування кістозних хвороб нирок для поглиблення знань про цю патологію. Обговорюються важливі нюанси ультразвукової діагностики кістозних хвороб нирок. Сучасне обладнання дозволяє діагностувати практично всі варіанти кістозної хвороби нирок. Навички ультразвукового дослідження або принаймні знання щодо сонографічної інтерпретації мають бути частиною навчання з нефрології.
Cystic diseases of the kidneys are a fairly common pathology, which has a negative impact on the course of underlying disease affecting the kidneys, or even being the primary renal pathology. The purpose of this review is to analyze the latest literature data on the etiology, pathogenesis, and diagnosis of cystic kidney diseases. This article highlights some aspects of the pathogenesis, diagnosis, and treatment of cystic kidney diseases in order to deepen knowledge about this pathology. Important nuances of ultrasound diagnosis of cystic kidney diseases are discussed. Modern equipment allows diagnosing almost all variants of cystic kidney disease. Training in ultrasound examination or at least knowledge of sonographic interpretation should be part of training in nephrology.
кістозна хвороба нирок; ультразвукова діагностика; проста кіста нирки; складна кіста нирки; ускладнена кіста нирки; комп’ютерна томографія; магнітно-резонансна томографія
cystic kidney disease; ultrasound diagnosis; simple kidney cyst; complex kidney cyst; complicated kidney cyst; computed tomography; magnetic resonance imaging
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- De Bruyn R, Gordon I. Imaging in cystic renal disease. Arch Dis Child. 2000 Nov;83(5):401-407. doi: 10.1136/adc.83.5.401.
- Fernández-de la Varga M, Pérez Valle I, Ordieres Díaz C, Amor Martín P, Álvarez Posadilla M, Huergo Fernández A. Large bowel obstruction secondary to a simple renal cyst: an exceptional complication. Rev Esp Enferm Dig. 2022 Jun;114(6):366-367. doi: 10.17235/reed.2022.8623/2022.
- Marte A, Pintozzi L. Laparoscopic treatment of symptomatic simple renal cysts in children: single-center experience. Pediatr Med Chir. 2018 May 24;40(1). doi: 10.4081/pmc.2018.168.
- Garfield K, Leslie SW. Simple Renal Cyst. 2023 Aug 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Mansour P, Ammar L, O Gomez Urena E, Chow A, El Labban M. A Unique Presentation of an Infected Renal Cyst: A Case Report and Literature Review. Cureus. 2023 Oct 30;15(10):e47966. doi: 10.7759/cureus.47966.
- Demuynck S, Lovinfosse P, Seidel L, et al. Standardized 4-point scoring scale of [18F]-FDG PET/CT imaging helps in the diagnosis of renal and hepatic cyst infections in patients with autosomal dominant polycystic kidney disease: a validation cohort. Clin Kidney J. 2023 Jul 5;16(12):2542-2548. doi: 10.1093/ckj/sfad159.
- Rehman A, Awais M, Baloch NU, Ather HM. Intraperitoneal marsupialization of a giant para-pelvic renal cyst: A case report. Can Urol Assoc J. 2014 Nov;8(11-12):E872-4. doi: 10.5489/cuaj.2072.
- Spahiu L, Behluli E, Grajçevci-Uka V, Liehr T, Temaj G. Joubert syndrome: Molecular basis and treatment. J Mother Child. 2023 Feb 22;26(1):118-123. doi: 10.34763/jmotherandchild.20222601.d-22-00034.
- Di Malta C, Zampelli A, Granieri L, et al. TFEB and TFE3 drive kidney cystogenesis and tumorigenesis. EMBO Mol Med. 2023 May 8;15(5):e16877. doi: 10.15252/emmm.202216877.
- Garfield K, Leslie SW. Medullary Sponge Kidney. 2023 May 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Chaubal R, Pokhriyal SC, Deshmukh A, Gupta U, Chaubal N. Multicystic Dysplastic Kidney Disease: An In-Utero Diagnosis. Cureus. 2023 Apr 18;15(4):e37786. doi: 10.7759/cureus.37786.
- Sigmon DF, Shikhman R, Nielson JL. Renal Cyst. 2023 Dec 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Sieben CJ, Harris PC. Experimental Models of Polycystic Kidney Disease: Applications and Therapeutic Testing. Kidney360. 2023 Aug 1;4(8):1155-1173. doi: 10.34067/KID.0000000000000209.
- Finnigan NA, Leslie SW. Polycystic Kidney Disease In Adults. 2023 Nov 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Simonini C, Fröschen EM, Nadal J, et al. Prenatal ultrasound in fetuses with polycystic kidney appearance - expanding the diagnostic algorithm. Arch Gynecol Obstet. 2023 Oct;308(4):1287-1300. doi: 10.1007/s00404-022-06814-8.
- Suwabe T, Morita H, Khasnobish A, Araoka H, Hoshino J. Microbiome of infected cysts, feces and saliva in patients with autosomal dominant polycystic kidney disease. CEN Case Rep. 2023 Aug;12(3):304-310. doi: 10.1007/s13730-022-00767-2.
- Pohl M, Bhatnagar V, Mendoza SA, Nigam SK. Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. Kidney Int. 2002 Jan;61(1):10-9. doi: 10.1046/j.1523-1755.2002.00086.x.
- Torres VE, Harris PC. Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases. Nat Clin Pract Nephrol. 2006 Jan;2(1):40-55; quiz 55. doi: 10.1038/ncpneph0070.
- Bergmann C, Frank V, Küpper F, et al. Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease. Mol Diagn Ther. 2006;10(3):163-74. doi: 10.1007/BF03256455.
- Winyard P, Chitty L. Dysplastic and polycystic kidneys: diagnosis, associations and management. Prenat Diagn. 2001 Nov;21(11):924-35. doi: 10.1002/pd.208.
- Aslam M, Watson AR; Trent & Anglia MCDK Study Group. Unilateral multicystic dysplastic kidney: long term outcomes. Arch Dis Child. 2006 Oct;91(10):820-3. doi: 10.1136/adc.2006.095786.
- Martín-Crespo R, Luque Mialdea R, Rodríguez Alarcón J, et al. New concepts in the natural history of multicystic dysplastic kidney. Cir Pediatr. 2007 Apr;20(2):75-8. Spanish.
- Hu WS, He J, Shen YM, Cai SP, Lu H. Ultrasonic diagnosis and prognosis of fetal multicystic kidney dysplasia. Zhonghua Yi Xue Za Zhi. 2007 Jun 5;87(21):1491-2. Chinese.
- Sarhan OM, Alghanbar M, Alsulaihim A, Alharbi B, Alotay A, Nakshabandi Z. Multicystic dysplastic kidney: Impact of imaging modality selection on the initial management and prognosis. J Pediatr Urol. 2014 Aug;10(4):645-9. doi: 10.1016/j.jpurol.2014.03.004.
- Rabelo EA, Oliveira EA, Silva GS, Pezzuti IL, Tatsuo ES. Predictive factors of ultrasonographic involution of prenatally detected multicystic dysplastic kidney. BJU Int. 2005 Apr;95(6):868-71. doi: 10.1111/j.1464-410X.2005.05418.x.
- Gambella A, Kalantari S, Cadamuro M, et al. The Landscape of HNF1B Deficiency: A Syndrome Not Yet Fully Explored. Cells. 2023 Jan 13;12(2):307. doi: 10.3390/cells12020307.
- Li Z, Zimmerman KA, Cherakara S, et al. A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models. Dis Model Mech. 2023 Jan 1;16(1):dmm049810. doi: 10.1242/dmm.049810.
- Kanauchi Y, Hashimoto M, Toda N, et al. Automatic Detection and Measurement of Renal Cysts in Ultrasound Images: A Deep Learning Approach. Healthcare (Basel). 2023 Feb 7;11(4):484. doi: 10.3390/healthcare11040484.
- Zhu M, Chu X, Liu C. Effects of Renal Cysts on Renal Function. Arch Iran Med. 2022 Mar 1;25(3):155-160. doi: 10.34172/aim.2022.26.
- Oh A, Bhardwaj L, Cacciamani G, Desai MM, Duddalwar VA. Cost-effectiveness of Contrast-Enhanced Ultrasound for Diagnosis and Active Surveillance of Complex Cystic Renal Lesions. Urol Pract. 2023 Jan;10(1):11-19. doi: 10.1097/upj.0000000000000354.
- Sharafeldeen M, Shaaban M, Afif AH, et al. Role of Angular Interface Sign in Characterizing Small Exophytic Renal Masses in Computed Tomography; Prospective Study. J Kidney Cancer VHL. 2023 Jun 28;10(2):33-39. doi: 10.15586/jkcvhl.v10i2.262.
- Kleiner B, Filly RA, Mack L, Callen PW. Multicystic dysplastic kidney: observations of contralateral disease in the fetal population. Radiology. 1986 Oct;161(1):27-9. doi: 10.1148/radiology.161.1.3532181.
- Atiyeh B, Husmann D, Baum M. Contralateral renal abnormalities in multicystic-dysplastic kidney disease. J Pediatr. 1992 Jul;121(1):65-7. doi: 10.1016/s0022-3476(05)82543-0.
- Kuwertz-Broeking E, Brinkmann OA, Von Lengerke HJ, Sciuk J, Fruend S, Bulla M, Harms E, Hertle L. Unilateral multicystic dysplastic kidney: experience in children. BJU Int. 2004 Feb;93(3):388-92. doi: 10.1111/j.1464-410x.2003.04623.x.
- Navascues del Río JA, Luque Mialdea R, Cerdá Berrocal J, Martín Crespo R, Arrojo Vila F. Multicystic renal dysplasia: changes in the contralateral urinary tract. Actas Urol Esp. 1996 Jun;20(6):564-8; discussion 568-9. Spanish.
- Cardona-Grau D, Kogan BA. Update on Multicystic Dysplastic Kidney. Curr Urol Rep. 2015 Oct;16(10):67. doi: 10.1007/s11934-015-0541-7.
- Hadlock FP, Deter RL, Carpenter R, Gonzalez ET, Park SK. Sonography of fetal urinary tract anomalies. AJR Am J Roentgenol. 1981 Aug;137(2):261-7. doi: 10.2214/ajr.137.2.261.
- Moazin MS, Ahmed S, Fouda-Neel K. Multicystic kidney in siblings. J Pediatr Surg. 1997 Jan;32(1):119-20. doi: 10.1016/s0022-3468(97)90114-7.
- Maayan A, Mashiach R, Kessler OJ, Meizner I, Merlob P. Prenatal diagnosis of crossed ectopic multicystic kidney. Am J Perinatol. 1998 Aug;15(8):499-502. doi: 10.1055/s-2007-994073.
- Della Corte M, Viggiano D. Wall Tension and Tubular Resistance in Kidney Cystic Conditions. Biomedicines. 2023 Jun 18;11(6):1750. doi: 10.3390/biomedicines11061750.
- Kakkar N, Menon S, Radotra BD. Histomorphology of renal dysplasia--an autopsy study. Fetal Pediatr Pathol. 2006 Mar-Apr;25(2):73-86. doi: 10.1080/15513810600788764.
- Vester U, Kranz B, Hoyer PF. The diagnostic value of ultrasound in cystic kidney diseases. Pediatr Nephrol. 2010 Feb;25(2):231-40. doi: 10.1007/s00467-008-0981-0.
- Riyach O, Ahsaini M, Tazi K, et al. A huge renal cyst mimicking ascites: a case report. BMC Res Notes. 2014 Jan 15;7:39. doi: 10.1186/1756-0500-7-39.
- Greenbaum LA. Renal dysplasia and MRI: a clinician's perspective. Pediatr Radiol. 2008 Jan;38 Suppl 1:S70-5. doi: 10.1007/s00247-007-0586-y.
- Alkhamis K, Alsasi O, Alzahrani M. The Modified Bosniak Classification for Intermediate and High-Risk Renal Cysts. Cureus. 2023 Apr 9;15(4):e37331. doi: 10.7759/cureus.37331.
- Herms E, Weirich G, Maurer T, et al. Ultrasound-based "CEUS-Bosniak"classification for cystic renal lesions: an 8-year clinical experience. World J Urol. 2023 Mar;41(3):679-685. doi: 10.1007/s00345-022-04094-0.
- Chandrasekar T, Clark CB, Gomella A, et al. Volumetric Quantitative Contrast-enhanced Ultrasonography Evaluation of Complex Renal Cysts: An Adjunctive Metric to the Bosniak Classification System to Predict Malignancy. Eur Urol Focus. 2023 Mar;9(2):336-344. doi: 10.1016/j.euf.2022.10.004.
- Nate T, Hatano K, Kato T, et al. Mucinous cystadenoma of the renal parenchyma presenting as a Bosniak IIF complex renal cyst. IJU Case Rep. 2023 Jan 18;6(2):150-153. doi: 10.1002/iju5.12576.
- Soleimani M. Not all kidney cysts are created equal: a distinct renal cystogenic mechanism in tuberous sclerosis complex (TSC). Front Physiol. 2023 Nov 8;14:1289388. doi: 10.3389/fphys.2023.1289388.
- Goksu SY, Leslie SW, Khattar D. Renal Cystic Disease. 2023 Oct 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Bakaj I, Pocai A. Metabolism-based approaches for autosomal dominant polycystic kidney disease. Front Mol Biosci. 2023 Feb 16;10:1126055. doi: 10.3389/fmolb.2023.1126055.
- van Leeuwaarde RS, Ahmad S, van Nesselrooij B, Zandee W, Giles RH. Von Hippel-Lindau Syndrome. 2000 May 17 [updated 2024 Feb 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024.
- Mikhail MI, Singh AK. Von Hippel-Lindau Syndrome. 2023 Jan 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Mahboob M, Rout P, Bokhari SRA. Autosomal Dominant Polycystic Kidney Disease. 2023 Oct 18. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.
- Di Pietro S, Torcitto AG, Marcantoni C, et al. Calculation of Kidney Volumes with Magnetic Resonance in Patients with Autosomal Dominant Polycystic Kidney Disease: Comparison between Methods. Diagnostics (Basel). 2023 Nov 30;13(23):3573. doi: 10.3390/diagnostics13233573.
- Barone S, Brooks M, Zahedi K, et al. Identification of an Electrogenic 2Cl-/H+ Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis. Am J Pathol. 2023 Feb;193(2):191-200. doi: 10.1016/j.ajpath.2022.10.007.
- Qiu ZW, Liu M, Zhou H, Yang BX. Inositol 1,4,5-triphosphate receptor 3 promotes renal cyst development in autosomal dominant polycystic kidney disease. Sheng Li Xue Bao. 2023 Jun 25;75(3):328-338. Chinese.
- Alamri N, Lanktree MB. Large Kidney Cysts in HNF1B Nephropathy Mimicking Autosomal Dominant Polycystic Kidney Disease. Can J Kidney Health Dis. 2024 Feb 15;11:20543581241232470. doi: 10.1177/20543581241232470.
- Jin C, Wei L, Yong Z, et al. Multiple and large simple renal cysts are associated with glomerular filtration rate decline: a cross-sectional study of Chinese population. Eur J Med Res. 2024 Jan 3;29(1):11. doi: 10.1186/s40001-023-01552-2.
- Teuwafeu DG, Dongmo A, Fomekong SD,et al. Acquired cystic kidney disease in patients on maintenance hemodialysis, prevalence and associated factors: a cross-sectional study. Pan Afr Med J. 2023 Aug 21;45:175. doi: 10.11604/pamj.2023.45.175.31773.